In 1320 A.D Andronikos Palaiologos Asanis occupied the castle. Of the 12 baronies, only 3 remained in Frankish hands. An attempt to recover the castle on 5 July 1465A.D was unsuccessful.

During the war between the Turks and Venetians Karytaina was temporarily under the dominion of the Venetians. According to the census of 1700 the region of Karytaina numbered 121 villages and 11,750 inhabitants.

Karytaina is built on the mountain side, located at ancient Vrenthis The area produced grain and silk. There was also a carpet industry and an outdoor market that operated every Monday.

The Karytaina was the headquarters from the first days of the revolution of 1821. The Karytaina Board was a local organization to coordinate the fight. Created on April 28 and appointed Theodoros Kolokotronis as leader of all local forces. On March 29 Kolokotronis' 6000 men had gathered and tried to seize Karytaina, but with the first exit of the Turks, the army was disbanded.

Without giving up and methodically setting up garrisons in topical sections of Tripoli (Levidi, Pianos, Chrysovitsi, Vervaina, Valtetsi, Trikorfo) in order to control the roads leading thither.
The Turkish center was a market centre and had a strong fortress, held by the Greeks in 1821. The 1826 was used as a base by Kolokotronis against Ibrahim and as a shelter for women and children.